Pictured above: Figure 2 from the article, "The impact of tau hyperphosphorylation at Ser262 on memory and learning after global brain ischaemia in a rat model of reversible cardiac arrest" (Shohreh Majd, John H.T. Power, Simon A. Koblar, Hugh J.M. Grantham) in Volume 2 (June 2017) of IBRO Reports.
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READ featured articles from Volume 2, June 2017 below
TBI-induced nociceptive sensitization is regulated by histone acetylation (Vol. 2, June 2017)
(D.-Y. Liang, P. Sahbaie, Y. Sun, K.-A. Irvine, X. Shi, A. Meidahl, P. Liu, T.-Z. Guo, D.C. Yeomans, J.D. Clark)
Chronic pain after traumatic brain injury (TBI) is very common, but the mechanisms linking TBI to pain and the pain-related interactions of TBI with peripheral injuries are poorly understood. In these studies we pursued the hypothesis that TBI pain sensitization is associated with histone acetylation in the rat lateral fluid percussion model. Our findings demonstrate that TBI induces sustained nociceptive sensitization, and changes in spinal neuronal histone proteins may play an important role.
(S. Majd, J.H.T. Power, S.A. Koblar, H.J.M. Grantham)
An increase in phosphorylated tau (p-tau) is associated with Alzheimer's disease (AD), and brain hypoxia. The aims of this study are to investigate the involvement of the main metabolic kinases, Liver Kinase B1 (LKB1) and Adenosine Monophosphate Kinase Protein Kinase (AMPK), in tau phosphorylation-derived memory impairment, and to study the potential contribution of the other tau kinases and phosphatases including Glycogen Synthase Kinase (GSK-3β), Protein kinase A (PKA) and Protein Phosphatase 2A (PP2A). Our data suggests a crucial role for a combined activation of tau kinases and phosphatases in adversely affecting memory and that hyperphosphorylation of tau in more than one specific site may be required to create memory deficits.
Griseum centrale, a homologue of the periaqueductal gray in the lamprey (Vol. 2, June 2017)
(I. Olsson, S.M. Suryanarayana, B. Robertson, S. Grillner)
Fear, a response to threatening stimuli and important for survival, is a behavior found throughout the animal kingdom. One critical structure involved in the expression of fear-related behavior is the periaqueductal gray (PAG) in mammals, and in the zebrafish, the griseum centrale. Here, we show in the lamprey, belonging to the oldest known living group of vertebrates, that a bilateral periventricular nucleus in the ventral mesencephalon has a similar location to that of the PAG and griseum centrale. Our results suggest that a structure homologous to the PAG/griseum centrale was present very early in vertebrate evolution.
International Brain Research Organization (IBRO) global neuroscience advocacy programme: Four imperative resolutions to strengthen neuroscience research and development in Malaysia (Vol. 2, June 2017)
(Pike-See Cheah, Syahrilnizam Abdullah, Hasnah Bahari, De Ming Chau, Omar Habib, Shariful Hasan, Melati Khalid, Pooi-Ling Mok, Norshariza Nordin, Niu-Jin Tan, Abhimanyu Veerakumarasivam, King-Hwa Ling)
Advocacy for neuroscience R&D has been poor in Malaysia due to different local requirements among neuroscience societies or non-profit organizations. The International Brain Research Organisation (IBRO) together with the Malaysian Society of Neurosciences and Universiti Putra Malaysia (UPM) decided to spearhead the task in concerting voices and efforts among all related parties in view of gaining better recognition from the national authority and related-community in general in Malaysia.